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It is interesting to note that other post-acute infection syndromes (PAIS) and some neuropsychiatric diseases such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), depression (especially the atypical/immunometabolic subtype (IMD) [86]) and others also have fatigue as a leading clinical symptom, which may serve as a model for investigating the mechanisms of fatigue and drawing conclusions regarding therapeutic options in long COVID

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Recent studies have shown that abiraterone acetate (Zytiga), an inhibitor of the cytochrome P450 enzyme CYP17, impedes androgen synthesis and thus lowers the level of circulating ligand, improving overall survival in well-powered, randomized phase III studies 163,164